Endocrine Abstracts

After almost 3 years since SARS-CoV-2infection was detected for the first time, knowledge about its repercussions on the thyroid gland function in the course of acute illness or in the post-COVID-19 are still poorly understood. This gland may be particularly susceptible to SARS-CoV-2 as this coronavirus enters cells through ACE-2 receptors, which are largely expressed in the thyroid gland. Through an observational, longitudinal and retrospective study, we investigated the seru...

Glycogen storage disease 1A (GSD1A) is an inherited metabolic disorder caused by glucose-6-phosphatase (G6PC) deficiency. Patients with GSD1A present disturbed glucose homeostasis and exhibit glycogen accumulation accompanied by hepatomegaly, hypoglycemia, lactic acidosis and hyperlipidemia. However, there are currently no licensed treatments for GSD1A, and human in vitro systems for disease modelling and drug screening are lacking. We aimed to develop a human hepatoc...

Introduction: Graves disease (GD) is a frequent cause of primary hyperthyroidism and often presents with weight loss. Weight gain beyond the premorbid state is often reported and could be a challenge during patient’s management. Treatment modalities, disease remission and biochemical parameters at the diagnosis have been described as predictors of weight changes in patients with GD. Objectives: To evaluate the determinants of weight changes in GD tr...

Introduction and Aims: Thyroid lesions constitute a frequent consultation in the area of endocrinology. Fine-needle aspiration (FNA) cytology is a gold standard for the evaluation of thyroid lesions, while ultrasound examination according to various thyroid imaging reporting and data system (TIRADS) criteria is gaining importance in the field. The aim of our study was to compare the sensitivity and specificity of both techniques in patients attended in thyroid lesion unit of o...

Introduction: Familial Adenomatous Polyposis (FAP) is an autosomal dominant disease classically characterized by the development of hundreds or thousands of adenomas in the rectum and colon during the second decade of life. Almost all patients will develop colorectal cancer (CRC) if not identified and treated at an early stage. It is a multisystem growth disorder so there is an increased risk of developing extraintestinal manifestations. In this context, an increase in adrenal...

A 52-year-old female patient with no previous history of interest, and with no prescribed habitual chronic treatment, was admitted to our hospital to be studied for symptomatic hypoglycemias of one month of evolution. Symptoms consisted of malaise, hunger, tremors and profuse sweating that disappeared with food ingestion. She referred hypoglycemic (up to 40 mg/dl) episodes daily, both in fasting and postprandial periods. She even suffered nocturnal episodes that woke her up. O...

Introduction: Cancer is the result of genetic and epigenetic alterations generating uncontrolled cell growth. These molecular changes maintain an immunosuppressive microenvironment allowing tumor spread. Immune checkpoint inhibitors (ICI) are novel therapeutic strategies in cancer treatment, promoting anti-tumor response by boosting cytotoxic T lymphocytes. Despite their high effectiveness, they can trigger the activation of diverse autoimmune diseases in genetically predispos...

Introduction: Familial Adenomatous Polyposis (FAP) syndrome is an autosomal dominant disorder associated with a high risk of multiple intestinal and extraintestinal cancers. They develop hundreds or thousands of adenomas in the rectum and colon during the second decade of life that. If they are not identified and treated, almost all patients develop colorectal cancer (CRC) and die by the age of 40-50 years. Thyroid carcinoma is a FAP manifestation with an unknown reported high...

Aim: To evaluate the diagnostic effectiveness of the first commercially available computer-aided diagnostic (CAD) imaging analysis system.Methods: Ultrasound images of 300 thyroid nodules (135 malignant) acquired prior to surgical treatment were retrospectively reviewed by a thyroid expert, and then the classification of each image was compared to the classification rendered by an image analysis program (AmCAD-UT®). The American Thyroid A...

Introduction: Central obesity and the consequent metabolic syndrome have global devastating effect on the health system due to their strong association with type 2 diabetes mellitus and cardiovascular disorder. There are contradictory results about the influence of insulin resistance and visceral adipose tissue on bone phenotype. The study was designed to evaluate the association between bone quality and bone mineral density (BMD) with bone marrow adipose tissue (MAT) as well ...